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Invest Radiol. 2003 May;38(5):281-7.

Embolization with autologous fibroblast-attached platinum coils in canine carotid artery aneurysms: histopathological differences from plain coil embolization.

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Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.



This study was designed to evaluate the effect of autologous fibroblast-attached platinum coils on the promotion of intra-aneurysmal thrombus organization.


Sidewall aneurysms were surgically created at common carotid arteries bilaterally in 5 dogs. Fibroblasts were obtained from the skins of the dogs and cultured and attached to unmodified platinum coils in a 5-day coculture. In each animal, one aneurysm was embolized with fibroblast-attached platinum coils (study group) and the other with plain platinum coils of the same size (control group).


All aneurysms were partially occluded; the mean occlusion rate was 67%. The histologic analyses performed 2 weeks after the embolization showed more advanced organization of intra-aneurysmal thrombus in the study group than in the control group (80% versus 53%, P = 0.02). Overgrowth of the organizing tissue and parent artery stenosis did not occur.


Our results suggest that autologous fibroblasts delivered with platinum coils could promote the organization of intra-aneurysmal thrombus. Although further research is needed, especially on the potential complications, endovascular treatment using autologous fibroblasts may be applied to aneurysm treatment.

[Indexed for MEDLINE]

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