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Ophthalmology. 2003 May;110(5):962-5.

Survival rates with uveal melanoma in the United States: 1973-1997.

Author information

1
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

PURPOSE:

To determine variations in 5-year relative survival rates with primary uveal melanoma in the United States over a 25-year period from 1973 to 1997.

DESIGN:

Systematic review of existing databases.

PARTICIPANTS:

Two thousand four hundred ninety-three patients with primary uveal melanoma, International Classification of Oncology [ICDO-2] codes C69.3 [choroid melanoma] and C69.4 [ciliary body and iris]) derived from Surveillance, Epidemiology, and End Results (SEER) program database in the United States from 1973 to 1997.

METHODS:

The patients were stratified according to the treatment (surgery or radiotherapy). The relative 5-year survival was calculated for 2054 patients diagnosed between 1973 and 1993 by the life table method using US life expectancy tables.

MAIN OUTCOME MEASURES:

The relative 5-year survival rate.

RESULTS:

Surgical treatment was performed in 1476 (72%) cases, and radiotherapy was given in 300 (15%) cases. The proportion of cases treated by radiotherapy increased progressively from 2% to 28% in 20 years. Relative 5-year survival rates ranged from 77% to 84% without a statistically significant variation.

CONCLUSIONS:

Advances made in the local methods of treatment of primary uveal melanoma have not led to an improvement in survival. Systemic approaches to management of uveal melanoma are warranted.

PMID:
12750098
DOI:
10.1016/S0161-6420(03)00077-0
[Indexed for MEDLINE]

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