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Bioorg Med Chem Lett. 2003 Jun 2;13(11):1919-22.

A novel estrogen receptor ligand template.

Author information

1
Bayer Research Center, Bayer Corporation, Pharmaceutical Division, 400 Morgan Lane, West Haven, CT 06516, USA. robert.sibley.b@bayer.com

Abstract

Three synthetic routes towards a novel estrogen receptor ligand template based on a rigid bicyclo-[3.3.1]-nonene core have been investigated. The prototype compound exhibits potent binding at the ERbeta receptor and promising estrogen receptor subtype selectivity.

PMID:
12749898
DOI:
10.1016/s0960-894x(03)00307-x
[Indexed for MEDLINE]

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