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Nature. 2003 May 15;423(6937):349-55.

Control of osteoblast function and regulation of bone mass.

Author information

1
Department of Bone Biology & Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA.

Abstract

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

PMID:
12748654
DOI:
10.1038/nature01660
[Indexed for MEDLINE]

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