Format

Send to

Choose Destination
See comment in PubMed Commons below
Heart. 2003 Jun;89(6):651-6.

Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?

Author information

  • 1Hannover Medical School, Leibniz Laboratory for Biotechnology and Artificial Organs, Hannover, Germany. heublein.bernd@mh-hannover.de

Abstract

OBJECTIVES:

To develop and test a new concept of the degradation kinetics of newly developed coronary stents consisting of magnesium alloys.

METHODS:

Design of a coronary stent prototype consisting of the non-commercial magnesium based alloy AE21 (containing 2% aluminium and 1% rare earths) with an expected 50% loss of mass within six months. Eleven domestic pigs underwent coronary implantation of 20 stents (overstretch injury).

RESULTS:

No stent caused major problems during implantation or showed signs of initial breakage in the histological evaluation. There were no thromboembolic events. Quantitative angiography at follow up showed a significant (p < 0.01) 40% loss of perfused lumen diameter between days 10 and 35, corresponding to neointima formation seen on histological analysis, and a 25% re-enlargement (p < 0.05) between days 35 and 56 caused by vascular remodelling (based on intravascular ultrasound) resulting from the loss of mechanical integrity of the stent. Inflammation (p < 0.001) and neointimal plaque area (p < 0.05) depended significantly on injury score. Planimetric degradation correlated with time (r = 0.67, p < 0.01).

CONCLUSION:

Vascular implants consisting of magnesium alloy degradable by biocorrosion seem to be a realistic alternative to permanent implants.

PMID:
12748224
PMCID:
PMC1767674
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center