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J Antimicrob Chemother. 2003 Jun;51(6):1373-6. Epub 2003 May 13.

Improving the mouse model for studying the efficacy of voriconazole.

Author information

1
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (7881), 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. jrgraybill@aol.com

Abstract

Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.

PMID:
12746374
DOI:
10.1093/jac/dkg261
[Indexed for MEDLINE]

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