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Int J Exp Diabesity Res. 2003 Jan-Mar;4(1):1-5.

Beta-cell expansion for therapeutic compensation of insulin resistance in type 2 diabetes.

Author information

1
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. sefrat@post.tau.ac.il

Abstract

Insulin resistance is the primary cause of type 2 diabetes. However, if compensated by increased insulin production, insulin resistance by itself does not lead to overt disease. Type 2 diabetes develops when this compensation is insufficient, due to defects in beta-cell function and in regulation of the beta-cell mass. beta-Cell transplantation, as well as approaches that replenish or preserve the endogenous beta-cell mass, may facilitate the treatment of type 2 diabetes in patients requiring exogenous insulin.

PMID:
12745664
PMCID:
PMC2480502
DOI:
10.1080/15438600303731
[Indexed for MEDLINE]
Free PMC Article

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