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Curr Opin Neurobiol. 2003 Apr;13(2):174-81.

Tracking cognitive processes with functional MRI mental chronometry.

Author information

1
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, Postbus 616, 6200 MD, Maastricht, The Netherlands. e.formisano@psychology.unimass.nl

Abstract

Functional magnetic resonance imaging (fMRI) is used widely to determine the spatial layout of brain activation associated with specific cognitive tasks at a spatial scale of millimeters. Recent methodological improvements have made it possible to determine the latency and temporal structure of the activation at a temporal scale of few hundreds of milliseconds. Despite the sluggishness of the hemodynamic response, fMRI can detect a cascade of neural activations - the signature of a sequence of cognitive processes. Decomposing the processing into stages is greatly aided by measuring intermediate responses. By combining event-related fMRI and behavioral measurement in experiment and analysis, trial-by-trial temporal links can be established between cognition and its neural substrate.

PMID:
12744970
DOI:
10.1016/s0959-4388(03)00044-8
[Indexed for MEDLINE]

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