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Trends Cell Biol. 2003 May;13(5):216-20.

In or out? The dynamics of Smad nucleocytoplasmic shuttling.

Author information

1
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Abstract

Members of the TGF-beta family of growth factors mediate their effects through activation of intracellular Smad proteins, which form transcriptionally competent complexes that accumulate in the nucleus. Recently, several reports have demonstrated that Smads actively shuttle between the cytoplasm and nucleus by distinct mechanisms. Here, we summarize what is known about the dynamics of Smad localization and suggest reasons why nucleocytoplasmic shuttling might be important for proper signal transduction.

PMID:
12742164
DOI:
10.1016/s0962-8924(03)00075-8
[Indexed for MEDLINE]

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