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Obes Res. 2003 May;11(5):603-5.

K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.

Author information

1
Department of Internal Medicine II, Hospital Clínico San Carlos, Madrid, Spain.

Abstract

OBJECTIVE:

To investigate the effect of the K121Q plasma cell membrane glycoprotein (PC-1) polymorphism on the components of the insulin resistance syndrome in a population-based nationwide multicenter study in Spain.

RESEARCH METHODS AND PROCEDURES:

The subjects of the study were 293 nonrelated adults (44.7% men and 55.3% women) ages 35 to 64 years randomly chosen from a nationwide population-based survey on obesity and related conditions, including insulin resistance and cardiovascular risk factors. Obesity-related anthropometric measurements included blood pressure, oral glucose tolerance test, lipid profile (total cholesterol, high-density lipoprotein- and low-density lipoprotein-cholesterol, and triglycerides), plasma leptin, insulin levels by radioimmunoassay, and insulin resistance (homeostasis model assessment). K121Q PC-1 genotypes were determined by restriction fragment-length polymorphism-polymerase chain reaction.

RESULTS:

Overall Q allele frequency was 0.14, with no differences between obese and nonobese individuals (0.15 vs. 0.13). After adjustment for sex, age, BMI, and degree of glucose tolerance, the Q allele was associated with high plasma leptin and triglyceride levels, but not with insulin resistance.

DISCUSSION:

The results showed that the K121Q PC-1 polymorphism in the Spanish population has no significant impact on insulin sensitivity.

PMID:
12740448
DOI:
10.1038/oby.2003.86
[Indexed for MEDLINE]
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