Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Philipp H Reichel; Christine Seemann; Elena Csernok; Jens-M Schröder; Antje Müller; Wolfgang L Gross; Hendrik Schultz

doi:10.1128/cdli.10.3.473-475.2003

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Clin Diagn Lab Immunol. 2003 May;10(3):473-5. doi: 10.1128/cdli.10.3.473-475.2003.

Authors

Philipp H Reichel¹, Christine Seemann, Elena Csernok, Jens-M Schröder, Antje Müller, Wolfgang L Gross, Hendrik Schultz

Affiliation

¹ Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt, Germany.

Abstract

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimicrobial Cationic Peptides
Blood Proteins / biosynthesis*
Blood Proteins / genetics
Blood Proteins / immunology
Endotoxins / pharmacology
Fibroblasts / metabolism*
Fibroblasts / microbiology
Humans
Interleukin-4 / pharmacology*
Membrane Proteins*
RNA, Messenger / analysis
Skin / cytology
Up-Regulation / drug effects

Substances

Antimicrobial Cationic Peptides
Blood Proteins
Endotoxins
Membrane Proteins
RNA, Messenger
bactericidal permeability increasing protein
Interleukin-4