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Fertil Steril. 2003 May;79(5):1194-8.

Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas.

Author information

1
Family Health International, Research Triangle Park, North Carolina 27709, USA. vgrigorieva@fhi.org

Abstract

OBJECTIVE:

This study was designed to evaluate the potential usefulness of the levonorgestrel-releasing intrauterine system (LNG IUS) in treating women with uterine leiomyomas.

DESIGN:

Prospective before-and-after study.

SETTING:

Family planning unit in an academic research institute.

PATIENT(S):

Sixty-seven women with uterine leiomyomas who chose the LNG IUS as their method of contraception.

INTERVENTION(S):

Clinical and ultrasound examinations were performed prior to and 3, 6, and 12 months after the LNG IUS insertion.

MAIN OUTCOME MEASURE(S):

Menstrual blood loss assessed with pictorial blood loss assessment charts, ferritin and hemoglobin concentrations, and uterine and leiomyoma volume.

RESULT(S):

Use of the LNG IUS was associated with a marked reduction in menstrual blood loss. After 12 months of use, the mean pictorial blood loss assessment chart score declined from 97 to 16 (P<.001). Hemoglobin and ferritin levels increased significantly over 1 year of use. Eighteen of 19 women (95%) who were anemic at the beginning of the study were no longer anemic at 12 months, as judged by hemoglobin levels. No pregnancies occurred during the study.

CONCLUSION(S):

The LNG IUS was associated with a profound reduction in menstrual blood loss. For women with leiomyomas of this size, the LNG IUS provides effective medical treatment of bleeding.

PMID:
12738516
[Indexed for MEDLINE]
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