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Obstet Gynecol. 2003 May;101(5 Pt 2):1104-7.

Prenatal diagnosis of methotrexate embryopathy.

Author information

1
Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois 60637, USA. jchapa33@yahoo.com

Abstract

BACKGROUND:

Methotrexate is an antineoplastic agent used by obstetrician-gynecologists for termination of early pregnancy. The drug is not always successful and is associated with a known array of malformations.

CASE:

We present a case of a failed pregnancy termination with methotrexate, which resulted in fetal anomalies. Ultrasound revealed absent or markedly shortened long bones, abnormal positioning of the hands, micrognathia, echogenic bowel, and a two-vessel umbilical cord. The patient elected to undergo pregnancy termination, and the ultrasound findings were confirmed at autopsy.

CONCLUSION:

Because of methotrexate's teratogenic potential, follow-up to confirm successful termination is necessary. Ultrasound evaluation of the fetus is indicated if pregnancy termination is unsuccessful.

PMID:
12738117
[Indexed for MEDLINE]
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