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Dev Cell. 2003 May;4(5):607-8.

Nuclear receptors orchestrate detoxification pathways.

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1
Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

PMID:
12737794
[Indexed for MEDLINE]
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