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J Clin Microbiol. 2003 May;41(5):2084-7.

Evaluation of a new serotyping assay for detection of anti-hepatitis C virus type-specific antibodies in serum samples.

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  • 1Laboratoire de Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, EA3406 ATHSCO, UFR Santé, Médecine, Biologie Humaine, Université Paris 13, 93009 Bobigny cedex, France.


The performance of a new version (HC03) of the hepatitis C virus (HCV) serotyping 1-6 assay (Abbott Murex Laboratories), a specific test for serological determination of HCV types, was evaluated using a selected panel of 180 HCV RNA-positive sera. HC03 was more sensitive than the current HC02 version, typing 53 (37.6%) of 141 samples which were not typable with HC02. Furthermore, the HC03 specificity was 94.1% as evaluated with a panel of 22 genotyped samples. This new version of the test improves the quality of the serological approach to HCV type determination.

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