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Circulation. 2003 May 13;107(18):2287-9. Epub 2003 May 5.

Electrical resynchronization: a novel therapy for the failing right ventricle.

Author information

1
Department of Pediatrics, Stanford University, 750 Welch Rd, Suite #305, Stanford, Calif 94304, USA. amdubin@leland.stanford.edu

Abstract

BACKGROUND:

Many patients with congenital heart disease develop right ventricular (RV) failure due to anatomy and prior therapy. RV problems may include right bundle-branch block (RBBB), volume loading, and chamber enlargement. Because the failing RV may have regional dyskinesis, we hypothesized that resynchronization therapy might augment its performance.

METHODS AND RESULTS:

We studied 7 patients with RV dysfunction and RBBB, using a predefined pacing protocol. QRS duration, cardiac index (CI), and RV dP/dt were measured in 4 different pacing states. Atrioventricular pacing improved CI and RV dP/dtmax and decreased QRS duration as compared with atrial pacing or sinus rhythm.

CONCLUSIONS:

Atrioventricular pacing in patients with RBBB and RV dysfunction augments RV and systemic performance. RV resynchronization is a promising novel therapy for patients with RV failure.

[Indexed for MEDLINE]

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