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Curr Opin Microbiol. 2003 Apr;6(2):120-4.

Regulatory roles for small RNAs in bacteria.

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Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.

Erratum in

  • Curr Opin Microbiol. 2003 Jun;6(3):324.


Small RNAs can act to regulate both the synthesis of proteins, by affecting mRNA transcription, translation and stability, and the activity of specific proteins by binding to them. As a result of recent genome-wide screens, around 50 small RNAs have now been identified in Escherichia coli. These include many that require the RNA-binding protein Hfq for their activity; most of these RNAs act by pairing with their target mRNAs. Small RNAs can both positively and negatively regulate translation, can simultaneously regulate multiple mRNA targets, and can change the pattern of polarity within an operon.

[Indexed for MEDLINE]

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