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Ann Neurol. 2003 May;53(5):673-6.

New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes.

Author information

1
NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, United Kingdom.

Abstract

In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium-enhancing lesions for dissemination in time at a 3-month follow-up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients.

PMID:
12731004
DOI:
10.1002/ana.10580
[Indexed for MEDLINE]

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