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Nat Genet. 2003 Jun;34(2):145-7.

Deficiency of Mbd2 suppresses intestinal tumorigenesis.

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1
Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK.

Abstract

Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.

PMID:
12730693
DOI:
10.1038/ng1155
[Indexed for MEDLINE]
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