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J Bacteriol. 2003 May;185(10):3238-43.

The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase.

Author information

1
Laboratoire de Microbiologie, Université Libre de Bruxelles, B-1070 Brussels, Belgium.

Abstract

We cloned, expressed, and purified the Escherichia coli YggH protein and show that it catalyzes the S-adenosyl-L-methionine-dependent formation of N(7)-methylguanosine at position 46 (m(7)G46) in tRNA. Additionally, we generated an E. coli strain with a disrupted yggH gene and show that the mutant strain lacks tRNA (m(7)G46) methyltransferase activity.

PMID:
12730187
PMCID:
PMC154064
[Indexed for MEDLINE]
Free PMC Article
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