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Bioorg Med Chem Lett. 2003 May 19;13(10):1821-4.

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. zhijian_lu@merck.com

Abstract

A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed.

PMID:
12729673
DOI:
10.1016/s0960-894x(03)00262-2
[Indexed for MEDLINE]

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