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Bioorg Med Chem Lett. 2003 May 19;13(10):1801-4.

5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA. hiroo_koyama@merck.com

Abstract

A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model.

PMID:
12729668
DOI:
10.1016/s0960-894x(03)00257-9
[Indexed for MEDLINE]

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