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Nat Rev Mol Cell Biol. 2003 May;4(5):397-407.

Sphingosine-1-phosphate: an enigmatic signalling lipid.

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1
Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA. sspiegel@vcu..edu

Abstract

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

PMID:
12728273
DOI:
10.1038/nrm1103
[Indexed for MEDLINE]
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