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Ann N Y Acad Sci. 2003 Apr;987:60-7.

Intrinsic T cell defects in systemic autoimmunity.

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Section of Rheumatology, Department of Internal Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA.


Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.

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