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Fitoterapia. 2003 Apr;74(3):231-6.

Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora.

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Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, B P 69, Congo.


The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic acid-induced writhing in mice. Only the dose of 8 ml/kg of essential oil, antagonized hyperexia induced by brewer's yeast. No effect on granuloma formation was observed.

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