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Cancer Cell. 2003 Apr;3(4):307-10.

Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer.

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Division of Molecular Medicine and Genetics and the Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.


A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer. Given the important role of Snail in repressing E-cadherin transcription and the function of E-cadherin as a tumor suppressor protein and regulator of epithelial architecture, the findings offer potentially significant new insights into cancer pathogenesis.

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