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Nat Rev Cancer. 2003 May;3(5):339-49.

Cancer and ageing: rival demons?

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Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, California 94720, USA.


Organisms with renewable tissues use a network of genetic pathways and cellular responses to prevent cancer. The main mammalian tumour-suppressor pathways evolved from ancient mechanisms that, in simple post-mitotic organisms, act predominantly to regulate embryogenesis or to protect the germline. The shift from developmental and/or germline maintenance in simple organisms to somatic maintenance in complex organisms might have evolved at a cost. Recent evidence indicates that some mammalian tumour-suppressor mechanisms contribute to ageing. How might this have happened, and what are its implications for our ability to control cancer and ageing?

[Indexed for MEDLINE]

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