Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Cancer. 2003 May;3(5):339-49.

Cancer and ageing: rival demons?

Author information

1
Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, California 94720, USA. jcampisi@lbl.gov

Abstract

Organisms with renewable tissues use a network of genetic pathways and cellular responses to prevent cancer. The main mammalian tumour-suppressor pathways evolved from ancient mechanisms that, in simple post-mitotic organisms, act predominantly to regulate embryogenesis or to protect the germline. The shift from developmental and/or germline maintenance in simple organisms to somatic maintenance in complex organisms might have evolved at a cost. Recent evidence indicates that some mammalian tumour-suppressor mechanisms contribute to ageing. How might this have happened, and what are its implications for our ability to control cancer and ageing?

PMID:
12724732
DOI:
10.1038/nrc1073
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center