Send to

Choose Destination
J Neuropsychiatry Clin Neurosci. 2003 Spring;15(2):161-7.

Nulliparity and late menopause are associated with decreased cognitive decline.

Author information

Department of Psychiatry, Naval Medical Center San Diego, California, USA.


Changes in Mini-Mental State Examination (MMSE) scores were examined over a median of 12.8 years in a population of 361 community-dwelling postmenopausal women who had never received estrogen replacement therapy. In a linear regression model that took into account age, education, race, surgical versus natural menopause, use of birth control pills, and MMSE score at baseline, it was found that nulliparous women and women who went through menopause later in life had significantly less cognitive decline. These results suggest that greater lifetime exposure to endogenous estrogen may be associated with less age-related cognitive decline.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center