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Ann N Y Acad Sci. 2003 Mar;983:208-12.

Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers.

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Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA.


Epigenetic mechanisms that result in aberrant gene expression are a prominent feature of many cancer types. One main epigenetic mechanism for gene silencing involves promoter hypermethylation. Type I and type II endometrial cancers exhibit differing clinical, histologic, and molecular genetic characteristics. We hypothesize that these differences also extend to epigenetic phenomena. Promoter methylation analysis of 11 genes in a panel of endometrial cancers supports this hypothesis. These initial data indicate that promoter hypermethylation events occur frequently in type 1 cancer and were not detected in type II cancers using this panel of loci. These data tend to support the hypothesis that type I and type II endometrial cancers will exhibit distinct patterns of gene silencing based on promoter hypermethylation events.

[Indexed for MEDLINE]

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