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Ann Allergy Asthma Immunol. 2003 Apr;90(4):416-21.

Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray.

Author information

1
Asthma and Allergy Associates, Upland, Pennsylvania, USA. smgawchik@aol.com

Abstract

BACKGROUND:

Cough commonly occurs as a symptom of seasonal allergic rhinitis (SAR), an inflammatory condition of the nasal mucous membranes that results in rhinorrhea, nasal stuffiness/congestion, nasal itching, and sneezing. Mometasone furoate nasal spray (MFNS, Nasonex, Schering, Kenilworth, NJ), an anti-inflammatory nasal corticosteroid, has been shown to be safe and effective in reducing the nasal inflammation of SAR.

OBJECTIVE:

To examine the effectiveness of MFNS in relieving SAR-associated cough, in addition to nasal symptoms.

METHODS:

This was a multicenter, randomized, double-blind study. Patients 12 years of age or older with > or = 1-year history of SAR symptoms, positive skin test to a prevailing seasonal allergen, moderate nasal symptoms, and moderate cough were treated for 14 days with MFNS 200 microg daily (n = 122) or placebo (n = 123).

RESULTS:

The group treated with MFNS showed significant improvement in the daytime cough severity score at endpoint compared with placebo (P = 0.049). Improvement in the nighttime cough severity score showed a trend in favor of MFNS treatment. Treatment with MFNS significantly improved total nasal symptoms in both the daytime and nighttime compared with placebo at endpoint (P < or = 0.017). Overall daytime symptom scores (cough + total nasal) improved significantly compared with placebo at endpoint (P = 0.005). Overall nighttime symptom scores improved significantly compared with placebo at endpoint (P = 0.028). Treatments were well tolerated, with no significant differences in the incidence of adverse events.

CONCLUSIONS:

MFNS is effective and well tolerated in the treatment of daytime cough associated with SAR.

PMID:
12722964
DOI:
10.1016/S1081-1206(10)61826-1
[Indexed for MEDLINE]
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