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J Virol. 2003 May;77(10):6055-61.

Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.

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1
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California 94305, USA.

Abstract

We identified an N-terminal amphipathic helix (AH) in one of hepatitis C virus (HCV)'s nonstructural proteins, NS5A. This AH is necessary and sufficient for membrane localization and is conserved across isolates. Genetically disrupting the AH impairs HCV replication. Moreover, an AH peptide-mimic inhibits the membrane association of NS5A in a dose-dependent manner. These results have exciting implications for the HCV life cycle and novel antiviral strategies.

PMID:
12719597
PMCID:
PMC154017
[Indexed for MEDLINE]
Free PMC Article
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