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Proc Natl Acad Sci U S A. 2003 May 13;100(10):6104-8. Epub 2003 Apr 28.

The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.

Author information

1
Department of Biochemistry, University of Oxford, United Kingdom.

Abstract

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

PMID:
12719519
PMCID:
PMC156333
DOI:
10.1073/pnas.1031527100
[Indexed for MEDLINE]
Free PMC Article

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