Format

Send to

Choose Destination
See comment in PubMed Commons below
J Struct Biol. 2003 Apr;142(1):170-9.

A deliberate approach to screening for initial crystallization conditions of biological macromolecules.

Author information

1
The Hauptman-Woodward Institute, 73 High Street, Buffalo, New York 14203, USA. detitta@hwi.buffalo.edu <detitta@hwi.buffalo.edu>

Abstract

A method to rationally predict crystallization conditions for a previously uncrystallized macromolecule has not yet been developed. One way around this problem is to determine initial crystallization conditions by casting a wide net, surveying a large number of chemical and physical conditions to locate crystallization leads. A facility that executes the rapid survey of crystallization lead conditions is described in detail. Results and guidelines for the initial screening of crystallization conditions, applicable to both manual and robotic setups, are discussed.

PMID:
12718929
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center