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J Struct Biol. 2003 Apr;142(1):144-53.

Membrane protein structural biology: the high throughput challenge.

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Department of Biochemistry, Drexel University College of Medicine, Mailstop 497, New College Building, 245 North 15th Street, Philadelphia, PA 19102-1101, USA. <>


Membrane proteins represent roughly one-third of the proteins encoded in the genome, yet fewer than 1% of the proteins are of known structure. High-throughput crystallography offers the hope of correcting this imbalance. In order for large-scale membrane protein structural biology to realize its full promise, however, significant technical challenges must be overcome, the two most substantial being facile protein overexpression and reliable methods for crystal growth.

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