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Mol Cell. 2003 Apr;11(4):848-50.

Distressing bacteria: structure of a prokaryotic detox program.

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1
MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.

Abstract

MazF and MazE are components of a chromosomal toxin-antitoxin system of Escherichia coli. In this issue of Molecular Cell, Kamada et al. describe the crystal structure of a MazE/MazF heterohexamer and propose that the mechanism of toxin-antidote recognition is common to other homologous chromosomal and plasmid-borne systems.

PMID:
12718870
[Indexed for MEDLINE]
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