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Neurobiol Aging. 2003 Jul-Aug;24(4):537-44.

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia.

Author information

1
Department of Veterans Affairs Medical Center, Magnetic Resonance Unit, 4150 Clement Street (116R), San Francisco, CA 94121, USA. valerie@itsa.ucsf.edu

Abstract

PURPOSE:

The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects.

METHODS:

16 C, 6 CI, and 7 D subjects of comparable age were studied with MRI twice, at least 1 year apart. Longitudinal change in total brain size was measured by several methods, including computerized segmentation, non-linear warping, and change in the fluid/tissue boundaries between cerebrospinal fluid (CSF) and brain. Change in hippocampal volume was measured by semi-automated methods, and ERC volumes were manually measured.

RESULTS:

The annual rate of atrophy was greater in D versus C and D versus CI for cortical gray matter (cGM) (P=0.009 and 0.002), hippocampus (P=0.0001 and 0.002), and for the change in the fluid/tissue boundary (P=0.03 and 0.03). The annual rate of atrophy of ERC was greater in both CI and D versus C (P=0.01 and 0.0002). No significant differences between groups were found using non-linear warping.

CONCLUSIONS:

In CI, the greatest annual rates of atrophy were in ERC, while in D the greatest annual rates of atrophy were in hippocampus and cortex. Progressive ERC atrophy was observed with a greater degree of cognitive impairment, while hippocampal and cortical atrophy were only observed in demented subjects.

PMID:
12714110
DOI:
10.1016/s0197-4580(02)00130-6
[Indexed for MEDLINE]
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