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Bioorg Med Chem. 2003 May 15;11(10):2313-9.

Design, synthesis and biological evaluation of oxazolidinone-quinolone hybrids.

Author information

1
Morphochem AG, Schwarzwaldallee 215, CH-4058 Basel, Switzerland. christian.hubschwerlen@morphochem.ch

Abstract

Oxazolidinone-quinolone hybrids that combine the pharmacophores of a quinolone and an oxazolidinone were synthesised and shown to be active against a variety of resistant and susceptible Gram-positive and fastidious Gram-negative organisms. The best compounds in this series overcome all types of resistance in relevant clinical Gram-positive pathogens. The nature of the spacer greatly influences the antibacterial activity. The dual mode of action could be demonstrated for compounds having a piperazinyl spacer. Antibacterial activity was higher at acidic pH.

PMID:
12713843
DOI:
10.1016/s0968-0896(03)00083-x
[Indexed for MEDLINE]

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