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Acta Neurol Scand. 2003 May;107(5):318-23.

Quantification of regional glial fibrillary acidic protein levels in Alzheimer's disease.

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1
Department of Veterans Affairs, Honolulu, HI, USA. ross@phri.hawaii-health.com

Abstract

OBJECTIVES:

Our objectives were to quantify glial fibrillary acidic protein (GFAP) in brains of Alzheimer's disease (AD) cases, and non-AD controls to determine the regions with the most severe gliosis in AD.

MATERIAL AND METHODS:

In a case control design, we used an enzyme-linked immunosorbent assay (ELISA) to quantify GFAP in frozen brain from four areas of neocortex in 10 AD cases, 10 age-matched controls, and 10 younger controls from the Honolulu-Asia Aging Study autopsy archive.

RESULTS:

Median age at death was 83.5 years for cases and age-matched controls, and 77 years for younger controls. For the AD cases compared with the age-matched controls, levels of GFAP in occipital (P=0.01), parietal (P=0.028), and temporal lobes (P=0.004) (but not frontal) were significantly higher in the cases. The median GFAP excess in AD cases compared with age matched controls was highest in the temporal lobe.

CONCLUSIONS:

Regional quantification of GFAP reveals that the glial response is most prominent in the temporal lobe in AD.

PMID:
12713522
[Indexed for MEDLINE]
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