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Gene Expr Patterns. 2003 May;3(2):179-92.

The developmental expression of cell cycle regulators in Xenopus laevis.

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Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XZ, UK.


Several cyclins and cdks have been cloned in Xenopus, but their developmental expression has not been thoroughly examined. We have analyzed the temporal and spatial expression of cdk1, cdk2, cdk4 and cyclins D1, D2, E, A1, A2 and B1 by in situ hybridization. The transcripts of these cyclins and cdks exhibit striking tissue-restricted expression patterns very early in development that cannot be strictly correlated with proliferation. While the cdks and their activating cyclins are expressed in somewhat overlapping patterns, they are not precisely coincident. Additionally, maternal and zygotic cyclin forms demonstrate markedly different expression patterns.

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