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Sci STKE. 2003 Apr 22;2003(179):RE8.

The structure and function of proline recognition domains.

Author information

1
Program in Biological Sciences, University of California San Francisco, 600 16th Street, San Francisco, CA 94143-2240, USA.

Abstract

One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling.

PMID:
12709533
DOI:
10.1126/stke.2003.179.re8
[Indexed for MEDLINE]

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