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Magn Reson Med. 2003 May;49(5):968-71.

Imaging single mammalian cells with a 1.5 T clinical MRI scanner.

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1
Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada. pgareau@imaging.robarts.ca

Abstract

In the present work, we demonstrate that the steady-state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom-built insertable gradient coil and customized RF coils can be used to detect individual SPIO-labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans.

PMID:
12704781
DOI:
10.1002/mrm.10417
[Indexed for MEDLINE]
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