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Genes Dev. 2003 Apr 15;17(8):1019-29.

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1.

Author information

1
H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa 33612, USA.

Abstract

Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone methyltransferases (HMTs) and elucidating the consequences of histone methylation, little is known about the recruitment of HMTs to regulatory regions of chromatin. Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.

PMID:
12704081
PMCID:
PMC196041
DOI:
10.1101/gad.1068003
[Indexed for MEDLINE]
Free PMC Article
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