Format

Send to

Choose Destination
Genome Biol. 2003;4(4):211. Epub 2003 Mar 31.

Modifications of histone cores and tails in V(D)J recombination.

Author information

1
Laboratory of Molecular Immunoregulation, SAIC-Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA. muegge@ncifcrf.gov

Abstract

The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.

PMID:
12702201
PMCID:
PMC154571
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center