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Indian J Ophthalmol. 2003 Mar;51(1):39-44.

Role of prophylactic intravitreal antibiotics in open globe injuries.

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Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.



To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma.


This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin.


The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity.


Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis.

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