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Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4.

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Author information

1
R47B, AP10, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. yunsong.tong@abbott.com

Abstract

A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.

PMID:
12699757
DOI:
10.1016/s0960-894x(03)00195-1
[Indexed for MEDLINE]

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