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J Theor Biol. 2003 May 7;222(1):23-36.

Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories.

Author information

1
Control and Dynamical Systems, California Institute of Technology, Mail Code 107-81 1200 East California Blvd., Pasadena, CA 91125, USA. ingalls@cds.caltech.edu

Abstract

A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction.

PMID:
12699732
DOI:
10.1016/s0022-5193(03)00011-0
[Indexed for MEDLINE]

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