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Curr Biol. 2003 Apr 15;13(8):R326-37.

Mechanisms of protein import into mitochondria.

Author information

1
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Strasse 7, D-79104 Freiburg, Germany. kaye.truscott@biochemie.uni-freiburg.de

Abstract

Apart from a handful of proteins encoded by the mitochondrial genome, most proteins residing in this organelle are nuclear-encoded and synthesised in the cytosol. Thus, delivery of proteins to their final destination depends on a network of specialised import components that form at least four main translocation complexes. The import machinery ensures that proteins earmarked for the mitochondrion are recognised and delivered to the organelle, transported across membranes, sorted to the correct compartment and assisted in overcoming energetic barriers.

PMID:
12699647
DOI:
10.1016/s0960-9822(03)00239-2
[Indexed for MEDLINE]
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