Format

Send to

Choose Destination
Curr Biol. 2003 Apr 15;13(8):618-26.

Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.

Author information

1
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California-San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA.

Abstract

BACKGROUND:

Understanding how dendrites establish their territory is central to elucidating how neuronal circuits are built. Signaling between dendrites is thought to be important for defining their territories; however, the strategies by which different types of dendrites communicate are poorly understood. We have shown previously that two classes of Drosophila peripheral da sensory neurons, the class III and class IV neurons, provide complete and independent tiling of the body wall. By contrast, dendrites of class I and class II neurons do not completely tile the body wall, but they nevertheless occupy nonoverlapping territories.

RESULTS:

By developing reagents to permit high-resolution studies of dendritic tiling in living animals, we demonstrate that isoneuronal and heteroneuronal class IV dendrites engage in persistent repulsive interactions. In contrast to the extensive dendritic exclusion shown by class IV neurons, duplicated class III neurons showed repulsion only at their dendritic terminals. Supernumerary class I and class II neurons innervated completely overlapping regions of the body wall, and this finding suggests a lack of like-repels-like behavior.

CONCLUSIONS:

These data suggest that repulsive interactions operate between morphologically alike dendritic arbors in Drosophila. Further, Drosophila da sensory neurons appear to exhibit at least three different types of class-specific dendrite-dendrite interactions: persistent repulsion by all branches, repulsion only by terminal dendrites, and no repulsion.

PMID:
12699617
DOI:
10.1016/s0960-9822(03)00207-0
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center