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Cell Mol Biol (Noisy-le-grand). 2002 Dec;48(8):939-54.

New directions in photodynamic therapy.

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Department of Chemistry and Chemical Engineering, The Royal Military College of Canada, P.O. Box 17000, Station Forces, Kingston, Ontario, Canada K7K 7B4.


Photodynamic therapy (PDT), a treatment approach that makes use of a photosensitizer to generate a localized toxic species in diseased tissue, has recently become an approved treatment modality. So far, however, only a handful of photosensitizers have received regulatory approval and for a small number of diseases. This chapter outlines the major limitations of PDT and speculates on the possible improvements that are required in order to advance PDT to a front line therapy. Seven areas of improvements are discussed: drug selectivity, drug delivery, light delivery, combination therapies, pigmented tumors, other potential uses, and protocol optimization. For each area, current limitations are discussed, and further required studies are recommended.

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