Chromosome assignment of eight SOX family genes in chicken

A Kuroiwa; M Uchikawa; Y Kamachi; H Kondoh; C Nishida-Umehara; J Masabanda; D K Griffin; Y Matsuda

doi:10.1159/000069803

Chromosome assignment of eight SOX family genes in chicken

Cytogenet Genome Res. 2002;98(2-3):189-93. doi: 10.1159/000069803.

Authors

A Kuroiwa¹, M Uchikawa, Y Kamachi, H Kondoh, C Nishida-Umehara, J Masabanda, D K Griffin, Y Matsuda

Affiliation

¹ Laboratory of Animal Cytogenetics, Center for Advanced Science and Technology, Hokkaido University, Sapporo, Japan. asatok@ees.hokudai.ac.jp

PMID: 12698002
DOI: 10.1159/000069803

Abstract

Chromosome locations of the eight SOX family genes, SOX1, SOX2, SOX3, SOX5, SOX9, SOX10, SOX14 and SOX21, were determined in the chicken by fluorescence in situ hybridization. The SOX1 and SOX21 genes were localized to chicken chromosome 1q3.1-->q3.2, SOX5 to chromosome 1p1.6-->p1.4, SOX10 to chromosome 1p1.6, and SOX3 to chromosome 4p1.2-->p1.1. The SOX2 and SOX14 genes were shown to be linked to chromosome 9 using two-colored FISH and chromosome painting, and the SOX9 gene was assigned to a pair of microchromosomes. These results suggest that these SOX genes form at least three clusters on chicken chromosomes. The seven SOX genes, SOX1, SOX2, SOX3, SOX5, SOX10, SOX14 and SOX21 were localized to chromosome segments with homologies to human chromosomes, indicating that the chromosome locations of SOX family genes are highly conserved between chicken and human.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chickens / genetics*
Chromosome Mapping
Chromosome Painting
Chromosomes, Mammalian
DNA-Binding Proteins / genetics
HMGB Proteins
High Mobility Group Proteins / genetics
Humans
In Situ Hybridization, Fluorescence
Neoplasm Proteins / genetics
Nuclear Proteins / genetics
SOX9 Transcription Factor
SOXB1 Transcription Factors
SOXB2 Transcription Factors
SOXD Transcription Factors
SOXE Transcription Factors
Transcription Factors / genetics*

Substances

DNA-Binding Proteins
HMGB Proteins
High Mobility Group Proteins
Neoplasm Proteins
Nuclear Proteins
SOX1 protein, human
SOX10 protein, human
SOX14 protein, human
SOX2 protein, human
SOX21 protein, human
SOX3 protein, human
SOX5 protein, human
SOX9 Transcription Factor
SOX9 protein, human
SOXB1 Transcription Factors
SOXB2 Transcription Factors
SOXD Transcription Factors
SOXE Transcription Factors
Sox10 protein, mouse
Sox14 protein, mouse
Sox2 protein, mouse
Sox21 protein, Gallus gallus
Sox3 protein, mouse
Sox9 protein, mouse
Transcription Factors